Making Realistic 3D Printed Organs to Plan Surgery

What if a surgical model not only could mimic the look and feel of a patient’s organ but also give surgeons quantitative feedback as they use it to practice the procedure? A team of scientists in the McAlpine Research Group at the University of Minnesota have been trying to answer this question, creating a prostate model that accomplishes exactly that.

In their article for the Annual Review of Analytical Chemistry, titled “3D Printed Organ Models for Surgical Applications,” Kaiyan Qiu, Ghazaleh Haghiashtiani, and Michael C. McAlpine from the University of Minnesota, review current materials used in 3D printed patient-specific organ models used in surgical pre-planning, as well as the state-of-the-art materials and techniques that allow them to replicate many kinds of human tissue.

The use of 3D models in medicine and anatomy is not new. Centuries ago, they were fashioned out of clay, wax, wood, glass, plaster, or even ivory, and they served as teaching tools or as illustrations of the mechanisms of disease, without having to resort to human dissection.

More recently, the boom in 3D printing technology has allowed medical professionals to visualize organs that might require surgery. Using data collected with imaging techniques such as CT scans, MRIs, or ultrasounds, these models can be fabricated to the exact specifications of a person’s organ.

This is of vital importance. A recent study has shown that an average of more than 250,000 people die each year in the United States as a result of medical errors, including more than 4,000 “never events” in surgery — events that should never have happened. Although complete elimination of errors is impossible, proper surgical planning and rehearsal can be key to reducing their occurrence. Model organs are quickly becoming invaluable tools to help prepare for surgery, not just allowing doctors to get a better feel for the organ on which they must operate, but also letting them plan the procedure. Recently, a 3D printed model of a patient’s hip joint changed the surgical team’s minds about the best treatment plan and resulted in performing a hip replacement instead of reconstruction of the damaged hip joint.

Current materials used in 3D printing have limitations, however. Compared to 2D slices of MRI or CT scans, 3D hard plastic models have helped increase the accuracy of surgeons by helping them to visualize the organ. They can also help inform the patients about their conditions and show inexperienced surgeons what to expect from the operation. Their main flaw is that they are not pliable enough to allow for surgical rehearsal. In contrast, rubber-like materials can provide a tactile feel closer to the actual organ they are meant to model and allow for cutting and suturing, but their properties do not precisely match those of an actual organ in elasticity, hardness, or color.

“These present the correct anatomy, but they’re incapable of providing quantitative feedback or even accurate tactile sensation,” said Dr. Qiu, a postdoctoral researcher in the McAlpine group and lead author of the article.

To remedy this, the three co-authors and their team have developed silicone-based 3D printing materials, or “inks,” that can be finely tuned to mimic these properties. Using a customized direct-write assembly 3D printer with a fine nozzle, they were able to construct a prostate model whose dimensions were obtained with MRI imaging and whose physical properties were established by mechanical tests on actual patient prostate samples, which informed their inks.

Screen Shot 2018-03-28 at 11.52.08They were also able to print and integrate electronic sensors onto and within the model that, when connected to a computer, provided quantitative feedback. This capability could enhance surgical precision in an actual procedure, as well as help train surgeons for steadiness, flexibility, and dexterity, just like a high-tech game of “Operation,” where a loud buzz goes off every time the player is too heavy-handed.

“When surgeons practice using different surgical tools, they can know how much force to apply as they get real-time feedback,” said Dr. Qiu. “They can adjust it and use that knowledge in real surgery to avoid damaging tissue.”

They’re not stopping there, setting their sights on more complex 3D models. Some could account for different types of tissue simultaneously printed with different inks. “We could replicate cancerous tissue and healthy tissue within the same model,” says Ms. Haghiashtiani. Another direction is to develop dynamic models, such as a 3D printed heart that can beat like a real one. A third idea is to create models that integrate sensors capable of taking various types of measurements at once, like temperature and multidirectional pressure.

Ultimately, they say, it is possible that their models could replace real organs.

“We are also working on bioprinting, where we can print organs that can replicate biological functions,” said Dr. Qiu.

“If we could get to this point, if we have the technology, you could say ‘why not use this for transplants?’” added Ms. Haghiashtiani.

Read more about prior limitations, current progress, and future perspectives in this important area in their Annual Review of Analytical Chemistry article. 

The Annual Review of Analytical Chemistry, first published in 2008, provides a perspective on the field of analytical chemistry. The journal draws from disciplines as diverse as biology, physics, and engineering, with analytical chemistry as the unifying theme.



The Science of Art and Plant Monitoring: Annual Review of Analytical Chemistry Volume 10

Browse the Annual Review of Analytical Chemistry Volume 10 table of contents.

AC10-artThere’s something magical about how scientific technology and techniques can peel back layers of paint and dust to reveal new information about an object or artist. Karen Trentelman’s article “Analyzing the Heterogeneous Hierarchy of Cultural Heritage Materials: Analytical Imaging” only increased my enjoyment of the topic. I was especially intrigued by the approach laid out in the introduction:

“In the creation of works of art, the extent to which human activity is necessary or able to control the final product can also be considered in terms of different length scales. Generally, the most important macroscale property, and the one entirely controlled (or at least actively sought) by the artist, is the overall appearance, broadly understood to include qualities such as color, texture, sheen, and shape. However, although the artist may control the final appearance through the selection and exploitation (whether deliberate or incidental) of specific mesoscale (or smaller) properties, the intrinsic micro- to nanoscale physics and chemistry that produce the desired macroscale appearance are out of the artist’s control. For example, a layer of varnish only a few tens of microns thick can dramatically change the appearance of a painting; the artist can control the choice of varnish and the thickness and method of application, but the index of refraction and surface tension properties that impart the desired saturation of color and surface appearance are controlled by nature.”

The ideas in Kwak et al.’s article “Nanosensor Technology Applied to Living Plant Systems” took me a bit by surprise. I knew that there was research that involved precision monitoring of agriculture, but I didn’t realize that plants could be actively managed at this level with great potential to change the way agriculture works:

“In the field of plant biology or agriculture, nanosensors have been used as nanobiosensors environmental pollution (25). Several nanosensors have been developed to detect contaminants, such as crystal violet or malachite green concentrations in seafood, and parathion residues or residues of organophosphorus pesticides on vegetables)…. The installation of nanosensors or nanoscale wireless sensors in living plants is currently applied to enable the real-time monitoring and early detection of potential problems related to biochemistry and metabolism.”

Suzanne K. Moses is Annual Reviews’ Senior Electronic Content Coordinator. For 15+ years, she has played a central role in the publication of Annual Reviews’ online articles. Not a single page is posted online without first being proofed and quality checked by Suzanne.